intermediate filament proteins การใช้

• Upon differentiation, nestin becomes downregulated and is replaced by tissue-specific intermediate filament proteins.
• Keratin 5, like other members of the keratin family, is an intermediate filament protein.
• These two categories also represent the first two categories of the superfamily of intermediate filament proteins.
• Keratins are the intermediate filament proteins that form a dense meshwork of filaments throughout the cytoplasm of epithelial cells.
• Thus they express the intermediate filament protein vimentin, a feature used as a marker to distinguish their mesodermal origin.
• These intermediate filament proteins are expressed mostly in nerve cells where they are implicated in the radial growth of the axon.
• The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins.
• The intermediate filament proteins in the cytokeratin group are almost exclusively found in epithelial cells, and so are often used for this purpose.
• Aggresome formation is accompanied by redistribution of the intermediate filament protein vimentin to form a cage surrounding a pericentriolar core of aggregated, ubiquitinated protein.
• The class III intermediate filament protein subunit peripherin is found in neurofilaments along with the class IV subunits in a few neurons, mostly in the peripheral nervous system.
• In agreement with this hypothesis, mutation of Aurora B target sites in intermediate filament proteins leads to defects in filament deformation and prevents the final stage of cytokinesis.
• Three corresponded to vimentin, an intermediate filament protein of 56 kDa believed to be a contaminant, and the other two matched the cDNA clone subsequently identified as NAPE-PLD.
• Aurora B targets a number of proteins that localize to the cleavage furrow, including the type-III intermediate filament proteins vimentin, desmin, and glial fibrillary acidic protein ( GFAP ).
• Nestin is an intermediate filament protein expressed in dividing cells during the early stages of development in the central nervous system ( CNS ), peripheral nervous system ( PNS ) and in myogenic and other tissues.
• Vimentin, an intermediate filament protein usually found in sarcoma, is ubiquitously ( nearly 100 % ) expressed diffusely throughout the cytoplasm of the rhabdoid cells, and is often intermingled with CK's in their whorled inclusions.
• Although the exact function is unknown in many tissues, podoplanin is generally receptive to detection via immunofluorescent staining and has been shown to co-localize with the protein nestin, a type VI intermediate filament protein expressed almost primarily in neural tissues.
• Rhabdoid cells often express protein products suggestive of aggressive, dedifferentiated cells, including neuroendocrine tumor-related products Vimentin, an intermediate filament protein usually associated with non-carcinomatous tumors ( i . e . sarcoma ), is ubiquitous in rhabdoid cells.